Understanding how chromosomes replicate in yeast
Replication Of Chromosomes In Budding Yeast
This study is looking at how DNA copies itself in yeast, focusing on how this process works with the surrounding DNA structure and gene activity, which could help us understand important biological processes related to diseases like cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11004289 on NIH RePORTER |
What this research studies
This research investigates the mechanisms of DNA replication in budding yeast, focusing on how the replication process interacts with chromatin structure and gene transcription. By utilizing advanced techniques that allow for single-molecule and single-nucleotide precision, the study aims to uncover how DNA synthesis can overcome obstacles such as RNA/DNA hybrids and G-quadruplex DNA. The research will also explore the role of specific proteins, like the DNA helicase Rrm3, in ensuring that DNA replication is completed efficiently and accurately. This work could provide insights into fundamental biological processes that are relevant to various diseases, including cancer.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with genetic conditions or cancers associated with DNA replication defects.
Not a fit: Patients with conditions unrelated to DNA replication or chromatin structure may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of DNA replication, which may inform new strategies for treating diseases related to DNA replication errors, such as cancer.
How similar studies have performed: Other research has shown success in understanding DNA replication mechanisms, but this approach utilizing single-molecule precision is relatively novel.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Whitehouse, Iestyn — Sloan-Kettering Inst Can Research
- Study coordinator: Whitehouse, Iestyn
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.