Understanding how chromosomes recombine during the formation of eggs and sperm
Recombination pathway and partner choices during meiosis
['FUNDING_OTHER'] · UNIVERSITY OF OREGON · NIH-11004953
This study looks at how chromosomes work together during the formation of eggs and sperm, using tiny worms to learn more about how they pick their partners for repair, which is important for healthy reproduction and preventing problems like infertility and birth defects.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF OREGON (nih funded) |
| Locations | 1 site (EUGENE, UNITED STATES) |
| Trial ID | NIH-11004953 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms of chromosome recombination during meiosis, which is the process that produces eggs and sperm. By studying the model organism Caenorhabditis elegans, the researchers aim to uncover how chromosomes choose their repair partners during this critical cell division. The study focuses on understanding the pathways and preferences for using homologous chromosomes versus sister chromatids in DNA repair, which is essential for maintaining genetic integrity and preventing issues like infertility and birth defects.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing infertility or those with a family history of genetic disorders.
Not a fit: Patients who do not have issues related to infertility or genetic abnormalities may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for infertility, cancer, and congenital abnormalities.
How similar studies have performed: Other research has shown success in understanding meiotic processes in model organisms, suggesting that this approach could yield valuable insights.
Where this research is happening
EUGENE, UNITED STATES
- UNIVERSITY OF OREGON — EUGENE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LIBUDA, DIANA ELIZABETH — UNIVERSITY OF OREGON
- Study coordinator: LIBUDA, DIANA ELIZABETH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers