Understanding how chromosomes pair during cell division
Homolog pairing in meiosis
This study is looking at how chromosomes work together during the process of making eggs and sperm, using tiny organisms like yeast and zebrafish to learn more about how their shape and movement can affect fertility and help us understand issues that might lead to birth defects or trouble getting pregnant.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-11098532 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind chromosome pairing, synapsis, and recombination during meiosis, which is crucial for proper cell division and fertility. By studying model organisms like budding yeast and zebrafish, the researchers aim to uncover how the three-dimensional organization of chromosomes affects their behavior and interactions. The project employs advanced imaging techniques to track chromosome movements and analyze how these movements contribute to reproductive success. Insights gained from this research could help explain the causes of chromosomal abnormalities that lead to birth defects and infertility.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing infertility or recurrent pregnancy loss due to chromosomal abnormalities.
Not a fit: Patients with chromosomal abnormalities not related to meiotic errors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential interventions for conditions related to chromosomal abnormalities, enhancing reproductive health.
How similar studies have performed: Previous research has shown success in understanding chromosome behavior in model organisms, suggesting that this approach could yield valuable insights for human health.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Burgess, Sean M — University of California at Davis
- Study coordinator: Burgess, Sean M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.