Understanding how chromosomes pair and segregate during reproduction in worms.
Official title: In vitro Reconstitution of the C. elegans Synaptonemal Complex
Funded at Johns Hopkins University · NIH-10998449 · Data updated 2026-11-12
This study is looking at how tiny worms help us understand how chromosomes pair up and separate during reproduction, which could help us learn more about infertility and genetic issues in people.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 1F31GM153163-01A1 |
| Project ID | NIH-10998449 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing infertility or those with known chromosomal abnormalities.
✕Less likely to help
Patients who do not have issues related to infertility or chromosomal abnormalities may not benefit from this research.
What this research studies
This research investigates the mechanisms of chromosome pairing and segregation during meiosis using the model organism Caenorhabditis elegans, a type of worm. It focuses on the synaptonemal complex, a protein structure essential for the proper alignment and recombination of chromosomes. By examining the molecular architecture of this complex, the research aims to uncover how defects in these processes can lead to infertility and chromosomal abnormalities. Patients may benefit from insights gained into the fundamental processes of reproduction and genetic inheritance.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of infertility and chromosomal disorders, potentially informing new treatments or preventive strategies.
How similar studies have gone: Previous research has shown success in understanding meiotic processes in model organisms, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Cesar-Hernandez, Brenda I — Johns Hopkins University
- Study coordinator: Cesar-Hernandez, Brenda I
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.