Understanding how chromosomes organize and function during cell division and reproduction
Chromosome organization and function in time and space: meiosis, mitosis and E. coli
This work helps us understand how chromosomes, the structures carrying our genetic information, move and organize themselves during cell division and sexual reproduction.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard University NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project ID | NIH-11091108 on NIH RePORTER |
What this research studies
We think of chromosomes as 'living, breathing objects' that constantly change their shape and position, which is essential for their basic jobs. This project compares how chromosomes behave during different types of cell division, including meiosis (which creates reproductive cells) and mitosis (which creates all other body cells), and even in bacteria. By looking at these fundamental processes, we aim to uncover common rules that govern how genetic material is handled. This includes studying how chromosomes pair up and exchange genetic information during sexual reproduction, a process crucial for healthy development.
Who could benefit from this research
Good fit: This foundational research does not involve direct patient participation, but future applications could benefit individuals affected by conditions related to chromosome abnormalities or reproductive health.
Not a fit: Patients seeking immediate treatment options or direct clinical interventions would not receive direct benefit from this basic science project.
Why it matters
Potential benefit: A deeper understanding of chromosome behavior could eventually help us understand the causes of birth defects and infertility, and potentially lead to new ways to prevent or address these issues.
How similar studies have performed: This project builds on previous discoveries about chromosome pairing and recombination, while also introducing novel approaches to dissect these complex processes.
Where this research is happening
Cambridge, United States
- Harvard University — Cambridge, United States (Active)
Researchers
- Principal investigator: Kleckner, Nancy E — Harvard University
- Study coordinator: Kleckner, Nancy E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.