Understanding how chromosomes move during the formation of reproductive cells
Mechanisms of chromosome motility during mammalian meiosis
This study looks at how chromosomes move during the process of making eggs and sperm, which is important for having healthy babies, and it aims to understand how problems in this movement can lead to issues like infertility and miscarriage.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-11105775 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind chromosome movement during meiosis, the process that produces gametes necessary for reproduction. It focuses on the role of specific protein complexes that connect chromosomes to the cell's nuclear envelope, facilitating their proper alignment and separation. By exploring these molecular interactions, the research aims to uncover the reasons behind issues like infertility and miscarriage, which can arise from improper chromosome segregation. The study employs a multi-disciplinary approach, integrating biophysical methods to analyze these cellular processes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing infertility or recurrent miscarriages due to chromosomal abnormalities.
Not a fit: Patients without any reproductive issues or those not affected by chromosomal disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and treatment options for fertility disorders.
How similar studies have performed: Previous research has shown promising results in understanding chromosome behavior during meiosis, suggesting that this approach could yield significant insights.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Nandakumar, Jayakrishnan — University of Michigan at Ann Arbor
- Study coordinator: Nandakumar, Jayakrishnan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.