Understanding how chromosomes fold during cell division in germ cells
Micromechanical basis of meiotic chromosome condensation and architecture
This study is looking at how chromosomes are arranged and folded in reproductive cells during the process of making eggs and sperm, which is important for ensuring everything works correctly to prevent issues like miscarriages and birth defects.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Urbana-Champaign NIH-funded |
| Lab location | 1 site (Champaign, United States) |
| Project ID | NIH-10909927 on NIH RePORTER |
What this research studies
This research investigates the complex process of how chromosomes are organized and folded in germ cells during meiosis, which is crucial for proper chromosome segregation. The study aims to uncover the mechanisms behind chromatin folding and its impact on gene expression, chromosome pairing, and recombination. By examining how these processes differ based on sex and developmental stage, the research seeks to provide insights into the causes of chromosomal abnormalities that can lead to miscarriages and birth defects. The methodology includes advanced techniques to analyze chromatin structure and dynamics.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals experiencing infertility issues or recurrent miscarriages, particularly those with a history of chromosomal abnormalities.
Not a fit: Patients who do not have any history of reproductive issues or chromosomal abnormalities may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and prevention of miscarriages and genetic disorders related to chromosomal abnormalities.
How similar studies have performed: Previous research has shown promising results in understanding chromatin organization and its implications for genetic stability, suggesting that this approach could yield valuable insights.
Where this research is happening
Champaign, United States
- University of Illinois at Urbana-Champaign — Champaign, United States (Active)
Researchers
- Principal investigator: Qiao, Huanyu — University of Illinois at Urbana-Champaign
- Study coordinator: Qiao, Huanyu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.