Understanding how chromosomes fold and interact in cells
Regulation of chromatin folding in space and time
This study is looking at how chromosomes are organized and interact inside our cells, which could help us learn more about how genes work and how they might be involved in diseases like cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11086729 on NIH RePORTER |
What this research studies
This research investigates the complex three-dimensional structures of chromosomes and how they fold and interact within the cell nucleus. By utilizing advanced techniques like fluorescent in situ hybridization (FISH), the study aims to uncover the mechanisms behind chromosome positioning and interactions at a single-cell level. The goal is to identify novel proteins that play a role in these processes, which could enhance our understanding of gene expression and its regulation in various diseases, including cancers.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic disorders or cancers that may be influenced by chromosomal architecture and gene expression.
Not a fit: Patients with conditions unrelated to chromosomal structure or gene regulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into gene regulation and potential therapeutic targets for cancer and other genetic disorders.
How similar studies have performed: Other research has shown promising results in understanding chromosomal interactions and their implications for gene regulation, indicating that this approach has potential for significant findings.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Joyce, Eric F. — University of Pennsylvania
- Study coordinator: Joyce, Eric F.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.