Understanding how chromosomes behave during the formation of eggs and sperm
Uncovering mechanisms controlling chromosome-specific behaviors during meiosis
['FUNDING_OTHER'] · UNIVERSITY OF GEORGIA · NIH-10876383
This study is looking at how chromosomes separate when making eggs and sperm, using fruit flies to learn more about a key structure that helps them pair up correctly, which could help us understand problems like infertility and birth defects.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF GEORGIA (nih funded) |
| Locations | 1 site (ATHENS, UNITED STATES) |
| Trial ID | NIH-10876383 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms that control how chromosomes segregate during meiosis, the process that produces eggs and sperm. By using the fruit fly Drosophila melanogaster as a model organism, the study aims to uncover the specific roles of the synaptonemal complex, a structure essential for chromosome pairing and recombination. The researchers will explore how variations in chromosome behavior can lead to issues such as infertility and birth defects, focusing on the differences in chromosome-specific recombination and segregation. This work could provide insights into the underlying causes of chromosomal abnormalities.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing infertility or those with a history of congenital birth defects in their families.
Not a fit: Patients who do not have concerns related to fertility or chromosomal abnormalities may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential interventions for fertility issues and congenital birth defects caused by chromosomal abnormalities.
How similar studies have performed: Other research has shown success in using model organisms like Drosophila to uncover genetic mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
ATHENS, UNITED STATES
- UNIVERSITY OF GEORGIA — ATHENS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BILLMYRE, KATHERINE ELISABETH — UNIVERSITY OF GEORGIA
- Study coordinator: BILLMYRE, KATHERINE ELISABETH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.