Understanding how chromosomes behave during reproduction
Large-scale regulation of meiotic chromosome dynamics
This study is looking at how chromosomes work together during reproduction, especially how they swap genetic information, and it's aimed at helping people understand issues like infertility and birth defects caused by chromosome problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-11094780 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that regulate chromosome interactions during sexual reproduction, focusing on how chromosomes exchange genetic information through crossovers. By studying model organisms like nematodes and budding yeast, the research aims to uncover the role of the synaptonemal complex, which is crucial for proper chromosome segregation. The team will employ advanced techniques such as genetic analysis, single-molecule tracking, and microscopy to explore the structure and dynamics of this complex. The findings could provide insights into the causes of infertility and congenital birth defects linked to chromosomal mis-segregation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing infertility or those with a family history of congenital birth defects.
Not a fit: Patients with chromosomal abnormalities unrelated to meiotic processes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for infertility and genetic disorders.
How similar studies have performed: Other research has shown success in understanding chromosome dynamics, but this approach focuses on large-scale regulation, making it a novel investigation.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Rog, Ofer — University of Utah
- Study coordinator: Rog, Ofer
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.