Understanding how chromosomes behave during cell division to prevent birth defects and infertility
Uncovering mechanisms controlling chromosome-specific behaviors during meiosis
This project looks at why chromosomes sometimes have the wrong number during cell division, which can lead to fertility problems and birth defects.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Georgia NIH-funded |
| Lab location | 1 site (Athens, United States) |
| Project ID | NIH-11106036 on NIH RePORTER |
What this research studies
Our bodies make eggs and sperm through a special cell division process called meiosis, where chromosomes must be perfectly divided. When chromosomes are not divided correctly, it can cause issues like infertility or birth defects. We are using fruit flies to learn more about how a structure called the synaptonemal complex helps chromosomes pair up and exchange genetic material. By understanding these basic steps, we hope to uncover why chromosome errors happen and how to prevent them.
Who could benefit from this research
Good fit: This foundational research is relevant to individuals and families affected by infertility or birth defects caused by chromosome abnormalities.
Not a fit: Patients will not receive direct medical benefit from participating in this basic science project, as it does not involve clinical trials or direct patient intervention.
Why it matters
Potential benefit: If successful, this work could lead to a better understanding of the causes of infertility and birth defects, potentially paving the way for new prevention strategies.
How similar studies have performed: While specific aspects of chromosome behavior are still being uncovered, previous studies have shown the utility of fruit fly models in understanding fundamental genetic processes relevant to human health.
Where this research is happening
Athens, United States
- University of Georgia — Athens, United States (Active)
Researchers
- Principal investigator: Billmyre, Katherine Elisabeth — University of Georgia
- Study coordinator: Billmyre, Katherine Elisabeth
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.