Understanding how chromosomes behave during cell division
Chromosome structural variants in meiosis
['FUNDING_OTHER'] · CASE WESTERN RESERVE UNIVERSITY · NIH-10891563
This study looks at how fruit flies repair their DNA during the process of making eggs and sperm, which can help us understand why some people might have trouble with fertility.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CASE WESTERN RESERVE UNIVERSITY (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-10891563 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms behind chromosome segregation during meiosis, focusing on how DNA double-stranded breaks are repaired. By studying the effects of chromosome structural variants in fruit flies, the researchers aim to uncover the factors that influence whether a repair results in a crossover or a non-crossover. This work involves genetic analyses to identify specific genes and pathways that affect these repair outcomes, which could have implications for understanding fertility issues in humans.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing difficulties conceiving or those with known chromosomal abnormalities.
Not a fit: Patients without any reproductive issues or chromosomal abnormalities may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of chromosome behavior, potentially aiding in the treatment of infertility and related reproductive issues.
How similar studies have performed: While the specific approach of using chromosome structural variants in this context is novel, related research has shown success in understanding chromosome behavior and its implications for fertility.
Where this research is happening
CLEVELAND, UNITED STATES
- CASE WESTERN RESERVE UNIVERSITY — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CROWN, KIMBERLY NICOLE — CASE WESTERN RESERVE UNIVERSITY
- Study coordinator: CROWN, KIMBERLY NICOLE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Candidate Disease Gene