Understanding how chromosomes are separated during cell division
Reconstitution and biophysical study of chromosome segregation machinery
This study is looking at how cells make sure their chromosomes are divided correctly during cell division, which is really important for keeping our cells healthy, and it uses special tools to closely watch and understand this process.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11009799 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind chromosome segregation during cell division, focusing on the mitotic spindle, a crucial molecular machine. By reconstituting spindle activities with purified components, the researchers develop biophysical tools to manipulate and observe these processes at the single molecule level. This approach allows for direct measurements of kinetochore activities, which are essential for ensuring accurate chromosome separation. The findings could lead to new insights into cellular processes that are vital for healthy cell division.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to chromosomal abnormalities or cancer, as they may benefit from advancements in understanding cell division.
Not a fit: Patients with conditions unrelated to chromosome segregation or cell division may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of chromosome segregation, potentially leading to improved treatments for cancers and other diseases related to cell division errors.
How similar studies have performed: Other research has shown success in understanding cellular mechanisms through biophysical approaches, indicating that this methodology is promising and has the potential for significant findings.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Asbury, Charles — University of Washington
- Study coordinator: Asbury, Charles
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.