Understanding How Chromosomes Are Passed On
Cell Biological mechanisms of centromere drive
['FUNDING_OTHER'] · UNIVERSITY OF PENNSYLVANIA · NIH-11091585
This project explores how chromosomes are correctly sorted during cell division, which is essential for healthy development.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-11091585 on ClinicalTrials.gov |
What this research studies
Our bodies rely on cells dividing correctly, making sure each new cell gets the right number of chromosomes. Sometimes, a part of the chromosome called the centromere can act "selfishly," trying to get passed on more often, especially in female egg cells. This project uses mouse models to understand how these selfish centromeres work and how the cell tries to keep things balanced. We are also looking at how centromere proteins have changed over time to manage this conflict, providing insights into fundamental cell biology.
Who could benefit from this research
Good fit: Patients with genetic conditions caused by errors in chromosome number or structure may find this foundational research relevant to their condition.
Not a fit: Patients seeking immediate new treatments or direct clinical interventions will not find direct benefit from this basic science project.
Why it matters
Potential benefit: This work could help us understand the basic causes of chromosomal abnormalities and genetic disorders that arise from errors in chromosome sorting.
How similar studies have performed: This project builds upon recent discoveries by the research team on how selfish centromeres interact with cell structures and how cells try to suppress these effects.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LAMPSON, MICHAEL — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: LAMPSON, MICHAEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.