Understanding how chromosomes are organized in individual cells
Probing the dynamics of chromosome organization in single cells
['FUNDING_OTHER'] · UNIVERSITY OF WASHINGTON · NIH-11135964
This study is looking at how DNA is organized inside individual cells, which is important for processes like reading genes and fixing DNA, to help us understand how changes in this organization might be linked to diseases like cancer.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WASHINGTON (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-11135964 on ClinicalTrials.gov |
What this research studies
This research investigates the organization of chromosomes within single mammalian cells, focusing on how DNA is packaged in a way that allows essential processes like transcription, replication, and repair to occur. Using advanced techniques like Hi-C, the study aims to map chromosome interactions and understand the structural features that may be disrupted in diseases such as cancer. By examining these features at the single-cell level, the research seeks to uncover the physical properties of genomic organization and their effects on cellular function.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cancers or developmental disorders that may be linked to chromosomal organization issues.
Not a fit: Patients without any chromosomal abnormalities or those not affected by cancer or developmental disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the mechanisms of cancer and developmental diseases, potentially informing more effective treatments.
How similar studies have performed: Other research has shown promising results using similar techniques to study chromosome organization, indicating that this approach has potential for significant discoveries.
Where this research is happening
SEATTLE, UNITED STATES
- UNIVERSITY OF WASHINGTON — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BELIVEAU, BRIAN JOSEPH — UNIVERSITY OF WASHINGTON
- Study coordinator: BELIVEAU, BRIAN JOSEPH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers