Understanding how chromosomes are organized in individual cells
Probing the dynamics of chromosome organization in single cells
['FUNDING_OTHER'] · UNIVERSITY OF WASHINGTON · NIH-10884220
This study is looking at how DNA is arranged inside individual cells to see how it affects important processes like reading genes and fixing damage, which could help us understand how problems with this organization might be linked to diseases like cancer.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WASHINGTON (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-10884220 on ClinicalTrials.gov |
What this research studies
This research investigates the organization of chromosomes within single mammalian cells, focusing on how DNA is packaged in a way that allows essential processes like transcription and repair to occur. Using advanced techniques like Hi-C, the study aims to map chromosome interactions and understand the physical properties of genomic features in individual cells. By addressing the limitations of current methods, the research seeks to uncover how disruptions in chromosome organization may relate to diseases such as cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cancers or developmental disorders that may be linked to chromosomal organization issues.
Not a fit: Patients with conditions unrelated to chromosomal organization or those who do not have cancer or developmental disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the mechanisms of cancer and developmental diseases, potentially informing future therapies.
How similar studies have performed: While the Hi-C technique has been successful in mapping chromosome interactions in large populations, this specific focus on single-cell dynamics is relatively novel and has not been extensively tested.
Where this research is happening
SEATTLE, UNITED STATES
- UNIVERSITY OF WASHINGTON — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BELIVEAU, BRIAN JOSEPH — UNIVERSITY OF WASHINGTON
- Study coordinator: BELIVEAU, BRIAN JOSEPH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers