Understanding how chromosomes are organized and move during cell division
Chromosome dynamics and organizations necessary for faithful chromosome segregation
This study is looking at how chromosomes behave during cell division and how mistakes in this process can lead to conditions like cancer and developmental issues, using special imaging techniques to better understand their organization in cells.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-10917219 on NIH RePORTER |
What this research studies
This research investigates the dynamics and organization of chromosomes during cell division, focusing on how errors in this process can lead to aneuploidy, which is linked to various cancers and developmental diseases. By using advanced super-resolution microscopy, the study aims to identify the spatial organization of chromosomes in mammalian cells during mitosis. The researchers will explore the concept of 'mitotic chromosome territories' and how these structures contribute to accurate chromosome segregation. This work could provide insights into the mechanisms that ensure proper cell division and may lead to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cancers or genetic conditions associated with aneuploidy.
Not a fit: Patients with conditions unrelated to chromosome segregation or those not experiencing aneuploidy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of cancers and developmental disorders caused by chromosome segregation errors.
How similar studies have performed: Previous research has shown promising results in understanding chromosome dynamics, but this specific approach to studying mitotic chromosome territories is relatively novel.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Suzuki, Aussie — University of Wisconsin-Madison
- Study coordinator: Suzuki, Aussie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.