Understanding how chromosomes are inherited during reproduction
Meiotic Chromosome Inheritance in Caenorhabditis
['FUNDING_OTHER'] · STANFORD UNIVERSITY · NIH-11053487
This study looks at how tiny worms make sure their chromosomes are passed down correctly during the creation of eggs and sperm, which is important for healthy reproduction and avoiding genetic problems.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STANFORD UNIVERSITY (nih funded) |
| Locations | 1 site (STANFORD, UNITED STATES) |
| Trial ID | NIH-11053487 on ClinicalTrials.gov |
What this research studies
This research investigates the molecular and cellular mechanisms that ensure chromosomes are accurately inherited during the process of meiosis, which is essential for producing gametes. By studying the model organism Caenorhabditis elegans, the research focuses on the events that lead to the proper segregation of chromosomes and the formation of crossovers, which are critical for genetic diversity. The study aims to uncover how cells balance the benefits of genetic recombination with the risks of potential damage to the genome, which can lead to conditions like aneuploidy and birth defects. Insights gained from this research could have implications for understanding human reproductive health and genetic disorders.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research include individuals with a history of miscarriages or congenital abnormalities linked to chromosomal issues.
Not a fit: Patients with non-genetic causes of reproductive issues may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and prevention of chromosomal abnormalities that cause miscarriages and congenital defects.
How similar studies have performed: Other research has shown success in understanding meiotic processes in model organisms, suggesting that this approach is promising and builds on established findings.
Where this research is happening
STANFORD, UNITED STATES
- STANFORD UNIVERSITY — STANFORD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VILLENEUVE, ANNE M — STANFORD UNIVERSITY
- Study coordinator: VILLENEUVE, ANNE M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: cancer progression