Understanding how chromosomes are inherited and maintained in cells
Regulation of chromosome inheritance and integrity
This study is looking at how chromosomes are passed on during cell division to help prevent diseases like cancer, using a special system from frog eggs to understand the building blocks of DNA and how certain genes might affect chromosome stability.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11056065 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind chromosome inheritance during cell division, which is crucial for preventing diseases like cancer. By utilizing a unique cell-free system derived from Xenopus eggs, the team explores the structure and function of nucleosomes, the building blocks of chromosomal DNA. They employ advanced techniques, including cryo-electron microscopy, to analyze how nucleosomes are regulated and how their dynamics affect chromosome integrity. The study also examines the role of specific genes linked to immunodeficiency and cancer, aiming to uncover their contributions to chromosomal stability.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic conditions related to chromosomal instability, such as Immunodeficiency, Centromere instability, and Facial anomalies (ICF) syndrome.
Not a fit: Patients with stable chromosomal integrity and no history of chromosomal abnormalities may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into cancer prevention and treatment by improving our understanding of chromosome stability.
How similar studies have performed: Previous research has shown promising results in understanding chromosomal dynamics, but this specific approach using Xenopus egg extracts is relatively novel.
Where this research is happening
New York, United States
- Rockefeller University — New York, United States (Active)
Researchers
- Principal investigator: Funabiki, Hironori — Rockefeller University
- Study coordinator: Funabiki, Hironori
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.