Understanding how chromosomes are inherited and ensuring their proper division
Centromere identity, strength, and regulation
['FUNDING_OTHER'] · UNIVERSITY OF PENNSYLVANIA · NIH-11011396
This study is looking at how cells make sure their chromosomes are split correctly during division, which is important for preventing genetic disorders, and it aims to create new types of artificial chromosomes that could help people with these conditions.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-11011396 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms that ensure chromosomes are accurately divided during cell division, focusing on the role of centromeres and kinetochores. By studying the molecular basis of centromere identity and the pathways that regulate chromosome segregation, the research aims to develop new types of human artificial chromosomes. Patients may benefit from insights gained about aneuploidy, which can lead to various genetic disorders. The approach combines biophysical methods and genetic analysis to explore these critical cellular processes.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit include individuals affected by aneuploidy or related genetic conditions.
Not a fit: Patients with conditions unrelated to chromosome segregation or those not affected by genetic disorders may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for genetic disorders caused by chromosome missegregation.
How similar studies have performed: Previous research has shown success in understanding chromosome segregation mechanisms, indicating that this approach builds on established findings.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BLACK, BEN E. — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: BLACK, BEN E.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.