Understanding how chromosomes are accurately divided during cell division
Mechanisms underlying chromosome segregation
This study looks at how cells make sure their chromosomes are divided correctly during cell division, using yeast to learn more about the tiny structures that help with this process, and the goal is to better understand issues like cancer and birth defects that can happen when things go wrong.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10933391 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that ensure accurate chromosome segregation during cell division, which is crucial for the development of all organisms. It focuses on understanding how kinetochores, the structures that attach chromosomes to spindle fibers, are assembled and how they function to maintain proper chromosome distribution. By using budding yeast as a model organism, the research employs biochemical and genetic techniques to explore these fundamental processes. The findings aim to shed light on the causes of aneuploidy, which is linked to various cancers and birth defects.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of cancers or congenital abnormalities related to chromosomal defects.
Not a fit: Patients with conditions unrelated to chromosome segregation or those who do not have a genetic predisposition to aneuploidy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing cancers and congenital abnormalities associated with chromosome segregation errors.
How similar studies have performed: Previous research has shown success in understanding chromosome segregation mechanisms, indicating that this approach is built on established scientific foundations.
Where this research is happening
Seattle, United States
- Fred Hutchinson Cancer Center — Seattle, United States (Active)
Researchers
- Principal investigator: Biggins, Susan — Fred Hutchinson Cancer Center
- Study coordinator: Biggins, Susan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.