Understanding how chromosomes and gene expression change in single cells
Dynamics of chromosome organization and chromatin states in single cells
This study looks at how the structure of chromosomes and the activity of genes change in individual mouse stem cells as they develop into different types of cells, helping us understand how cells decide what they will become.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | California Institute of Technology NIH-funded |
| Lab location | 1 site (Pasadena, United States) |
| Project ID | NIH-10902119 on NIH RePORTER |
What this research studies
This research investigates the dynamic processes of chromosome organization and gene expression in single cells, particularly during cellular differentiation. By utilizing advanced imaging techniques and tracking methods, the study aims to capture how chromatin states and chromosome arrangements influence each other in real-time. The research focuses on mouse embryonic stem cells to explore the transition from a pluripotent state to a more differentiated state, providing insights into the underlying mechanisms of gene regulation and cellular identity.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with conditions related to cellular differentiation, such as certain cancers or genetic disorders.
Not a fit: Patients with stable, non-differentiating conditions or those not affected by chromosomal or epigenetic changes may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding cellular differentiation, which may improve regenerative medicine and cancer therapies.
How similar studies have performed: Other research has shown success in using advanced imaging techniques to study chromosomal dynamics, making this approach promising yet still innovative.
Where this research is happening
Pasadena, United States
- California Institute of Technology — Pasadena, United States (Active)
Researchers
- Principal investigator: Cai, Long — California Institute of Technology
- Study coordinator: Cai, Long
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.