Understanding how chromosome variations affect reproduction
Chromosome structural variants in meiosis - Equipment supplement
This study looks at how certain changes in chromosomes affect the way cells divide during reproduction, using fruit flies to help us understand this process better, which could eventually help with problems like developmental diseases and miscarriages.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11043080 on NIH RePORTER |
What this research studies
This research investigates the process of meiosis, which is crucial for successful reproduction. It focuses on how chromosome structural variants, particularly inversions, influence the formation of crossovers and noncrossovers during DNA recombination. By using the fruit fly Drosophila melanogaster as a model organism, the study aims to uncover the mechanisms behind these decisions in chromosome behavior. This knowledge could help address issues related to aneuploidy, a leading cause of developmental diseases and miscarriages.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing recurrent miscarriages or developmental issues potentially linked to chromosomal abnormalities.
Not a fit: Patients with no history of reproductive issues or chromosomal abnormalities may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential interventions for conditions related to chromosomal abnormalities in human reproduction.
How similar studies have performed: Previous research has shown promising results in understanding chromosome behavior during meiosis, suggesting that this approach could yield valuable insights.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Crown, Kimberly Nicole — Case Western Reserve University
- Study coordinator: Crown, Kimberly Nicole
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.