Understanding how chromosome structure affects blood pressure regulation
Role of chromatin conformation in BP Regulation
This study is looking at how our genes and chromosomes might affect blood pressure, using animal models to see what happens when certain parts of chromosomes are changed, so we can better understand high blood pressure and how to manage it.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project ID | NIH-10903757 on NIH RePORTER |
What this research studies
This research investigates the genetic factors that influence blood pressure, focusing on how the structure of chromosomes may affect the interaction of genes related to blood pressure regulation. By using animal models, researchers will disrupt specific chromosome regions to observe changes in blood pressure control. Advanced genomic techniques will be employed to map the interactions between these genes and their regulatory sequences, providing insights into the genetic basis of hypertension.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of hypertension or those who have been diagnosed with high blood pressure.
Not a fit: Patients with hypertension caused solely by non-genetic factors, such as lifestyle choices or secondary causes, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing and treating hypertension, potentially reducing the risk of cardiovascular diseases.
How similar studies have performed: Previous research has shown promise in understanding genetic influences on blood pressure, but this approach focusing on chromatin conformation is relatively novel.
Where this research is happening
Tucson, United States
- University of Arizona — Tucson, United States (Active)
Researchers
- Principal investigator: Geurts, Aron M — University of Arizona
- Study coordinator: Geurts, Aron M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.