Understanding how chromosome loops affect gene regulation and immune responses
Official title: Exploring a Functional Role of Chromosome Loop Extrusion Direction on Regulating Genome Biology
Funded at Children's Hosp of Philadelphia · NIH-10737648 · Data updated 2026-11-12
This study looks at how certain structures in our DNA help control the way immune cells develop, which could help us understand why some people might be more prone to immune-related diseases.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | November 8, 2022 |
| Project end | October 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $267,000 |
| NIH project number | 5R21AI174545-02 |
| Project ID | NIH-10737648 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with genetic disorders affecting immune function or those with a family history of immune-related diseases.
✕Less likely to help
Patients with conditions unrelated to immune function or chromosome architecture may not receive any benefit from this research.
What this research studies
This research investigates the role of chromosome loop formation in regulating gene expression, particularly focusing on how these loops influence the development of immune cells. By examining the mechanisms of loop extrusion mediated by proteins like Cohesin and CTCF, the study aims to uncover how the directionality of these loops impacts the recombination of antigen receptor genes, which are crucial for immune function. The research utilizes models of lymphocyte development to explore these processes, providing insights into how changes in chromosome architecture can lead to various diseases. Patients may benefit from a better understanding of genetic factors influencing immune responses and disease susceptibility.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating immune-related diseases by targeting the genetic mechanisms involved in immune cell development.
How similar studies have gone: Previous research has shown that understanding chromosome topology can significantly impact our knowledge of genetic regulation and disease, indicating that this approach has potential for success.
Where this research is happening
-
Children's Hosp of Philadelphia
Philadelphia, United States Active
Researchers
- Principal investigator: Bassing, Craig H — Children's Hosp of Philadelphia
- Study coordinator: Bassing, Craig H
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.