Understanding how chromosome instability in cancer cells affects tumor growth and the immune response
Official title: Dissecting the impact of tumor-intrinsic chromosomal instability on the cancer ecosystem
Funded at Weill Medical Coll of Cornell Univ · NIH-11092908 · Data updated 2026-11-12
This study is looking at how mistakes in cell division in cancer can affect the tumor and help it grow, with the hope of finding new ways to improve treatments and boost the immune system's ability to fight cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | June 8, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $717,795 |
| NIH project number | 5R01CA280572-03 |
| Project ID | NIH-11092908 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with cancers characterized by chromosomal instability, such as certain types of breast cancer.
✕Less likely to help
Patients with cancers that do not exhibit chromosomal instability may not benefit from this research.
What this research studies
This research investigates how ongoing chromosome missegregation in cancer cells, known as chromosomal instability (CIN), influences the tumor environment and promotes cancer progression. By manipulating the rates of chromosome missegregation, researchers aim to understand its effects on immune suppression, drug resistance, and metastasis. The study utilizes advanced experimental tools to explore the relationship between CIN and the immune system's response to tumors, potentially revealing new insights into cancer biology and treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches that enhance anti-tumor immunity and improve treatment outcomes for cancer patients.
How similar studies have gone: Other research has shown promising results in understanding the role of chromosomal instability in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
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Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Laughney, Ashley Marie — Weill Medical Coll of Cornell Univ
- Study coordinator: Laughney, Ashley Marie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.