Understanding how chromosomal instability affects radiation sensitivity in meningioma tumors
Chromosomal instability and radiation sensitivity in meningioma
This study is looking at how a new test can help doctors figure out which patients with meningiomas, a common type of brain tumor, might do better with radiation therapy after surgery, so they can improve treatment options for those who need it.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11036124 on NIH RePORTER |
What this research studies
This research investigates meningiomas, the most common primary brain tumors, focusing on the challenges of predicting patient outcomes after surgery and the effectiveness of radiation therapy. The study aims to validate a new biomarker related to chromosomal instability that could better identify patients who would benefit from radiation treatment. By using advanced mouse models and human cell lines, the research will explore how chromosomal instability contributes to tumor growth and resistance to therapy. Ultimately, the goal is to improve treatment strategies for patients with high-grade meningiomas.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with meningiomas, especially those with high-grade tumors or those who have undergone surgery.
Not a fit: Patients with low-grade meningiomas or those who are not candidates for surgery or radiation therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatment options for meningioma patients, particularly those with high-grade tumors resistant to radiation therapy.
How similar studies have performed: Previous research has shown promising results in using biomarkers for risk stratification in other tumor types, suggesting potential success for this novel approach in meningiomas.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Chen, William C — University of California, San Francisco
- Study coordinator: Chen, William C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.