Understanding how chromosomal instability affects lung cancer spread to the brain and immune response
Official title: Chromosomal instability as a driver of non-small cell lung cancer immune evasion and brain metastasis
Funded at Columbia University Health Sciences · NIH-10842249 · Data updated 2026-11-12
This study is looking at how certain changes in lung cancer cells might help the cancer spread to the brain and resist treatments, with the goal of finding new ways to help patients with non-small cell lung cancer.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 5F30CA281104-02 |
| Project ID | NIH-10842249 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include patients diagnosed with non-small cell lung cancer, particularly those with mutations in the STK11 gene.
✕Less likely to help
Patients with other types of lung cancer or those without chromosomal instability may not benefit from this research.
What this research studies
This research investigates the role of chromosomal instability (CIN) in non-small cell lung cancer (NSCLC) and its connection to brain metastasis. By analyzing patient data and conducting laboratory studies, the research aims to uncover how CIN contributes to the aggressive nature of certain lung cancers and their ability to evade the immune system. The study focuses on tumors with specific mutations that increase the risk of brain metastasis and resistance to immunotherapy. Through this work, researchers hope to identify new therapeutic targets that could improve treatment outcomes for affected patients.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating lung cancer that has spread to the brain, potentially improving survival rates and quality of life for patients.
How similar studies have gone: Other research has shown promising results in understanding the mechanisms of chromosomal instability in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Caprio, Lindsay Anne — Columbia University Health Sciences
- Study coordinator: Caprio, Lindsay Anne
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.