Understanding how chromosomal instability affects cancer response to radiation
Chromosomal Instability as a Marker and Mechanism of Radiation Response
This study is looking at how changes in chromosomes affect how well radiation therapy works for people with cervical and throat cancers, with the goal of creating more personalized treatment plans that fit each patient's unique tumor.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-10865119 on NIH RePORTER |
What this research studies
This research investigates the role of chromosomal instability (CIN) in the response of cervical and oropharyngeal cancers to radiation therapy. By examining how CIN influences tumor biology, the study aims to tailor radiotherapy treatments to improve outcomes for patients with these cancers. The approach involves analyzing the rates of chromosome missegregation and their impact on cell survival and treatment efficacy. This could lead to more personalized treatment strategies that consider individual tumor characteristics.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with locally advanced cervical or oropharyngeal cancers, particularly those with HPV-related tumors.
Not a fit: Patients with cancers unrelated to HPV or those who are not undergoing radiation therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved survival rates and reduced side effects for patients undergoing radiation therapy for cervical and oropharyngeal cancers.
How similar studies have performed: Previous research has shown that understanding chromosomal instability can lead to significant advancements in cancer treatment, suggesting a promising avenue for this investigation.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Cosper, Pippa F — University of Wisconsin-Madison
- Study coordinator: Cosper, Pippa F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.