Understanding how chromium interacts with DNA
Molecular Structure of Chromium-DNA Adducts
This study is looking at how a form of chromium interacts with DNA, which could help us understand how it might lead to mutations and cancer, especially for people who might be exposed to chromium through breathing or eating.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama in Tuscaloosa NIH-funded |
| Lab location | 1 site (Tuscaloosa, United States) |
| Project ID | NIH-10358312 on NIH RePORTER |
What this research studies
This research investigates the molecular structure of chromium-DNA complexes to understand how chromium, particularly in its trivalent form, binds to DNA and potentially causes mutations and cancer. The study aims to characterize these interactions at a molecular level, which has been largely unexplored. By using advanced techniques, the researchers will analyze how chromium affects DNA structure and function, which could provide insights into its carcinogenic properties. This work is crucial for determining the risks associated with chromium exposure, especially through inhalation or ingestion.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with known exposure to chromium, particularly those with a history of inhalation or ingestion of chromium compounds.
Not a fit: Patients who have no history of chromium exposure or related health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding of chromium's role in cancer development, potentially informing prevention strategies and treatment options.
How similar studies have performed: While there has been significant research on chromium's effects, the specific molecular characterization of chromium-DNA complexes is relatively novel and has not been extensively studied.
Where this research is happening
Tuscaloosa, United States
- University of Alabama in Tuscaloosa — Tuscaloosa, United States (Active)
Researchers
- Principal investigator: Vincent, John Bertram — University of Alabama in Tuscaloosa
- Study coordinator: Vincent, John Bertram
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.