Understanding how chromatin structure affects gene regulation
Mechanism of chromatin accessibility, 3D chromosome organization, and their functions in gene regulation
This study is looking at how the structure of DNA in our cells affects how genes work, using special techniques to compare different ways of studying this, and it aims to help us understand diseases that happen when genes don’t function properly.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State University, the NIH-funded |
| Lab location | 1 site (University Park, United States) |
| Project ID | NIH-11236331 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind chromatin accessibility and 3D chromosome organization, which are crucial for regulating gene expression in cells. By using advanced techniques like ATAC-seq and MNase-seq, the study aims to compare these methods to better understand how chromatin structure influences gene activity. The goal is to identify discrepancies in data from these techniques and improve their interpretability, which could lead to better insights into gene regulation. Patients may benefit from this research as it could enhance our understanding of diseases caused by gene misregulation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic conditions or diseases that involve misregulation of gene expression.
Not a fit: Patients with conditions unrelated to chromatin structure or gene regulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for diagnosing and treating diseases linked to gene regulation.
How similar studies have performed: Previous research has shown success in using ATAC-seq and MNase-seq for studying chromatin accessibility, but this specific comparative approach is novel.
Where this research is happening
University Park, United States
- Pennsylvania State University, the — University Park, United States (Active)
Researchers
- Principal investigator: Bai, Lu — Pennsylvania State University, the
- Study coordinator: Bai, Lu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.