Understanding how chromatin structure affects gene regulation
Mechanism of chromatin accessibility, 3D chromosome organization, and their functions in gene regulation
This study is looking at how the way our DNA is organized can affect gene activity, which is important for understanding diseases like cancer, and it aims to find new ways to help patients through better treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State University, the NIH-funded |
| Lab location | 1 site (University Park, United States) |
| Project ID | NIH-11004951 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind chromatin structure and its role in regulating genes. It focuses on two main areas: first, identifying pioneer factors that help open chromatin at the nucleosome level, and second, studying how the three-dimensional organization of chromosomes influences gene regulation. By using innovative methods, the research aims to uncover how misregulation of these factors can lead to diseases like cancer. Patients may benefit from insights gained into gene regulation that could inform new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cancers or developmental disorders that may be influenced by chromatin structure and gene regulation.
Not a fit: Patients with conditions unrelated to chromatin structure or gene regulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for cancers and developmental diseases linked to chromatin misregulation.
How similar studies have performed: Previous research has shown promising results in understanding chromatin dynamics and its implications in gene regulation, suggesting that this approach has potential for success.
Where this research is happening
University Park, United States
- Pennsylvania State University, the — University Park, United States (Active)
Researchers
- Principal investigator: Bai, Lu — Pennsylvania State University, the
- Study coordinator: Bai, Lu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.