Understanding how chromatin structure affects B-cell lymphoma development
Chromatin Architecture Regulatory Mechanisms in Pathogenesis of B-Cell Lymphomas
['FUNDING_P01'] · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · NIH-11015498
This study is looking at how the structure of DNA in B-cells might contribute to the development of B-cell lymphomas, a type of cancer, to help find new ways to treat it.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NEW YORK UNIVERSITY SCHOOL OF MEDICINE (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11015498 on ClinicalTrials.gov |
What this research studies
This research investigates the role of chromatin architecture in the development of B-cell lymphomas, a type of cancer affecting the immune system. By examining how specific regions of chromatin interact and regulate gene expression, the study aims to uncover the mechanisms that lead to cancerous changes in B-cells. The researchers utilize advanced techniques like CRISPR screening and the Pore-C method to analyze the formation of chromatin structures and their impact on gene regulation. This work could provide insights into how B-cell lymphomas arise and progress, potentially leading to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with B-cell lymphomas or those at high risk for developing this type of cancer.
Not a fit: Patients with other types of cancers or non-cancerous conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with B-cell lymphomas.
How similar studies have performed: Other research has shown promising results in understanding chromatin dynamics in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
NEW YORK, UNITED STATES
- NEW YORK UNIVERSITY SCHOOL OF MEDICINE — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MELNICK, ARI M. — NEW YORK UNIVERSITY SCHOOL OF MEDICINE
- Study coordinator: MELNICK, ARI M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.