Understanding how chromatin remodeling complexes affect gene expression and disease.
Genome-wide mechanisms and dynamics of ATP-dependent chromatin remodeling complexes
This study is looking at how certain protein complexes help control gene activity by changing the structure of DNA, which could help us understand their role in diseases like cancer and neurological disorders.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project ID | NIH-11051902 on NIH RePORTER |
What this research studies
This research investigates the role of ATP-dependent chromatin remodeling complexes, which are essential for regulating gene expression by altering the structure of chromatin. By examining how these complexes interact with DNA and their subunit composition, the study aims to uncover the mechanisms behind their function in various diseases, including cancers and neurological disorders. The approach involves advanced biochemical techniques to analyze the binding and activity of these complexes across the genome, providing insights into their specific roles in different cell types and conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cancers or neurological disorders linked to mutations in chromatin remodeling genes.
Not a fit: Patients with conditions unrelated to chromatin remodeling or those without genetic mutations in the relevant pathways may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies targeting chromatin remodeling complexes for patients with cancers and other genetic disorders.
How similar studies have performed: Previous research has shown promising results in understanding chromatin remodeling complexes, indicating that this approach could yield valuable insights.
Where this research is happening
Omaha, United States
- University of Nebraska Medical Center — Omaha, United States (Active)
Researchers
- Principal investigator: Brahma, Sandipan — University of Nebraska Medical Center
- Study coordinator: Brahma, Sandipan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.