Understanding how chromatin remodeling affects heart development and disease
Function and regulation of chromatin remodeling complexes in cardiac development and disease
This study is looking at how certain proteins help form heart muscle cells and how problems with these proteins can cause heart defects, with the hope that understanding these processes will lead to better treatments for people with congenital heart disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-10906924 on NIH RePORTER |
What this research studies
This research investigates the role of chromatin remodeling complexes in the formation of heart muscle cells and how their dysfunction can lead to congenital heart disease. By focusing on specific proteins like SMYD1 and the MLL4-COMPASS complex, the research aims to uncover the mechanisms that regulate gene expression during cardiac development. Patients may benefit from insights gained about the genetic and molecular factors contributing to heart malformations, potentially leading to improved treatments or preventive strategies. The research employs advanced techniques such as ChIP sequencing to analyze chromatin structure and gene regulation.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with congenital heart disease or those at risk due to genetic factors.
Not a fit: Patients with heart conditions unrelated to chromatin remodeling or those without congenital heart disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for congenital heart disease.
How similar studies have performed: Previous research has shown promising results in understanding chromatin remodeling in other contexts, suggesting potential for success in this area as well.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Conlon, Frank Leo — Univ of North Carolina Chapel Hill
- Study coordinator: Conlon, Frank Leo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.