Understanding how chromatin remodeling affects gene expression in cancer
Structure-activity relationships governing mammalian SWI/SNF chromatin remodeling activity as a function of chromatin state
This study is looking at how certain proteins that help shape our genes behave differently in cancer cells compared to normal cells, which could help us understand cancer better and find new ways to treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dana-Farber Cancer Inst NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11063170 on NIH RePORTER |
What this research studies
This research investigates the role of specific protein complexes that remodel chromatin, which is the material that makes up our genes. By examining how these complexes are altered in various cancers, the study aims to uncover the mechanisms that regulate gene expression. The researchers will analyze how different histone modifications and protein interactions influence the activity of these complexes in both normal and cancerous cells. This work could lead to a better understanding of cancer biology and potential new therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with cancers that have mutations in chromatin regulatory proteins.
Not a fit: Patients with cancers not associated with chromatin remodeling or those without genetic mutations in relevant pathways may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating cancers associated with chromatin remodeling defects.
How similar studies have performed: Previous research has shown that targeting chromatin remodeling complexes can lead to significant advancements in cancer treatment, indicating a promising avenue for this study.
Where this research is happening
Boston, United States
- Dana-Farber Cancer Inst — Boston, United States (Active)
Researchers
- Principal investigator: Kadoch, Cigall — Dana-Farber Cancer Inst
- Study coordinator: Kadoch, Cigall
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.