Understanding how chromatin remodeling affects gene activity and specificity
Determinants of genome-wide activity and specificity of SWI/SNF family chromatin remodeling
This study is looking at how certain protein complexes in our cells help control gene activity, which could affect various diseases, and it aims to find out how changing these proteins can influence how genes are turned on or off.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10844360 on NIH RePORTER |
What this research studies
This research investigates the role of ATP-dependent chromatin remodelers, specifically BAF (SWI/SNF) complexes, in regulating gene expression and their impact on various diseases. By utilizing advanced techniques in epigenetics, chemical biology, and microscopy, the team aims to uncover how these complexes are regulated and how they influence DNA accessibility and transcription. The study will involve manipulating BAF activity in living cells and measuring the effects on gene expression through innovative methods. This could lead to new insights into the mechanisms of gene regulation in both healthy and diseased states.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic or epigenetic disorders that involve disruptions in chromatin remodeling.
Not a fit: Patients with conditions unrelated to chromatin remodeling or gene expression regulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for manipulating gene expression, potentially improving treatments for diseases linked to chromatin remodeling.
How similar studies have performed: Previous research has shown that understanding chromatin remodeling can lead to significant advancements in gene therapy and treatment of genetic disorders, indicating a promising avenue for this study.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Hodges, Hamilton Courtney — Baylor College of Medicine
- Study coordinator: Hodges, Hamilton Courtney
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.