Understanding how chromatin remodeler CHD2 affects a type of brain cancer in children.
Official title: Roles of Chromatin Remodeler CHD2 in Diffuse Midline Glioma with Onco-Histone Mutations
Funded at Columbia University Health Sciences · NIH-11042261 · Data updated 2026-11-12
This study is looking at how a protein called CHD2 affects a type of brain cancer called diffuse midline gliomas, especially in kids and teens with certain gene changes, to find new ways to treat this tough illness.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | March 20, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $436,819 |
| NIH project number | 5R01NS132344-03 |
| Project ID | NIH-11042261 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children and adolescents diagnosed with diffuse midline gliomas, particularly those with H3K27M mutations.
✕Less likely to help
Patients with other types of brain tumors or those without the specific H3K27M mutations may not benefit from this research.
What this research studies
This research investigates the role of the chromatin remodeler CHD2 in diffuse midline gliomas, particularly those with specific mutations in histone proteins. By using advanced techniques like CRISPR/Cas9, the study aims to uncover how these mutations influence gene expression and tumor behavior. The goal is to identify new drug targets that could lead to better treatments for this aggressive form of brain cancer in children and adolescents. Patients may benefit from insights that could lead to more effective therapies.
Why it matters
Potential benefit: If successful, this research could lead to the development of novel treatments for a deadly brain cancer affecting children.
How similar studies have gone: Other research has shown promise in targeting chromatin remodelers for cancer treatment, suggesting potential success for this approach.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Zhang, Zhiguo — Columbia University Health Sciences
- Study coordinator: Zhang, Zhiguo
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.