Understanding how chromatin regulation affects DNA processes and cancer development
Molecular mechanisms and functions of global chromatin control
['FUNDING_OTHER'] · FRED HUTCHINSON CANCER CENTER · NIH-11000819
This study looks at how certain proteins help control the way DNA is packaged in cells, which is important for things like cell growth and repair, using yeast to learn more about these processes; the goal is to understand how changes in these proteins might lead to cancer and find new ways to treat it.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | FRED HUTCHINSON CANCER CENTER (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-11000819 on ClinicalTrials.gov |
What this research studies
This research investigates the molecular mechanisms behind chromatin regulation, which plays a crucial role in various DNA-dependent processes such as transcription, DNA replication, and repair. By using budding yeast as a model organism, the study aims to uncover how chromatin is reprogrammed during critical events like cell development and the cell cycle. The findings could provide insights into how mutations in chromatin regulators contribute to cancer, potentially leading to new therapeutic strategies. The research combines experimental techniques with molecular biology to explore these fundamental biological questions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cancers associated with chromatin regulation mutations.
Not a fit: Patients with non-cancerous conditions unrelated to chromatin regulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of cancer mechanisms and the development of targeted therapies.
How similar studies have performed: Previous studies have shown promising results in understanding chromatin regulation, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
SEATTLE, UNITED STATES
- FRED HUTCHINSON CANCER CENTER — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TSUKIYAMA, TOSHIO — FRED HUTCHINSON CANCER CENTER
- Study coordinator: TSUKIYAMA, TOSHIO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers