Understanding how chromatin organization affects gene regulation in human cells
Official title: Mapping heterochromatin organization with high-throughput imaging
Funded at Oklahoma Medical Research Foundation · NIH-11019324 · Data updated 2026-11-12
This study is looking at how the way certain parts of our DNA are organized in human cells can affect how our genes work and how our cells function, which could help us understand more about health and disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oklahoma Medical Research Foundation NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project start | June 10, 2025 |
| Project end | April 30, 2030 |
| Funding year | 2025 |
| Award (this year) | $341,000 |
| NIH project number | 1P20GM156711-01 |
| Project ID | NIH-11019324 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic conditions or diseases that may be influenced by chromatin organization.
✕Less likely to help
Patients with conditions unrelated to chromatin structure or gene regulation may not benefit from this research.
What this research studies
This research investigates the organization of heterochromatin within the nucleus of human cells, focusing on how this organization influences gene regulation and cellular function. By altering the spatial arrangement of chromatin and observing the resulting effects, the study aims to uncover the mechanisms that drive chromatin self-association. The approach involves comparing different types of heterochromatin and identifying the proteins involved in their organization, using advanced imaging techniques to track changes in chromatin structure.
Why it matters
Potential benefit: If successful, this research could lead to new insights into gene regulation, potentially impacting treatments for diseases linked to chromatin organization.
How similar studies have gone: Previous research has shown promising results in understanding chromatin organization, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Oklahoma Medical Research Foundation
Oklahoma City, United States Active
Researchers
- Principal investigator: Finn, Elizabeth H — Oklahoma Medical Research Foundation
- Study coordinator: Finn, Elizabeth H
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.