Understanding how chromatin influences T-cell development
A chromatin-based timer controlling T-cell development
This study is looking at how changes in the way genes are turned on and off affect the development of T-cells, which are important for fighting infections and diseases, and it hopes to find new ways to understand and treat cancers that might be linked to these processes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10764256 on NIH RePORTER |
What this research studies
This research investigates the role of chromatin modifications in the development of T-cells, which are crucial for the immune system. By using a unique mouse model that allows researchers to track the activation of specific genes involved in T-cell lineage commitment, the study aims to uncover how epigenetic mechanisms control gene expression. This could lead to a better understanding of how disruptions in these processes can lead to cancers. Patients may benefit from insights gained about T-cell development and its implications for cancer treatment.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with cancers that affect the immune system or those interested in understanding T-cell related therapies.
Not a fit: Patients with non-cancerous conditions unrelated to T-cell development may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing immune responses in cancer treatment.
How similar studies have performed: Other research has shown promising results in understanding epigenetic mechanisms in cell differentiation, suggesting potential for success in this area as well.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Kueh, Hao Yuan — University of Washington
- Study coordinator: Kueh, Hao Yuan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.