Understanding how chromatin fragments move in aging and senescence
Official title: Nucleus-to-cytoplasm trafficking of chromatin fragments in senescence and aging
Funded at Massachusetts General Hospital · NIH-11079659 · Data updated 2026-11-12
This study is looking at how tiny pieces of DNA in aging cells can move out of the cell's nucleus and cause inflammation, which can make it harder for the body to heal and stay healthy as we get older; the goal is to find new ways to help older adults feel better by targeting these processes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $539,708 |
| NIH project number | 5R01AG082785-03 |
| Project ID | NIH-11079659 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing age-related diseases or conditions associated with cellular senescence.
✕Less likely to help
Patients who are not experiencing age-related conditions or are younger individuals may not benefit from this research.
What this research studies
This research investigates the movement of chromatin fragments from the nucleus to the cytoplasm in cells that are aging or have entered a state of senescence. It focuses on how these fragments contribute to inflammation and impair tissue renewal, which are common issues in age-related diseases. By studying the mechanisms behind this process, the research aims to identify potential therapeutic targets that could help clear senescent cells and improve health outcomes for older adults. The approach includes using genetic and pharmacological tools to manipulate these cellular processes.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that promote healthy aging and reduce the impact of age-related diseases.
How similar studies have gone: Other research has shown success in targeting the senescence-associated secretory phenotype (SASP) and its role in aging, indicating that this approach has potential.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Dou, Zhixun — Massachusetts General Hospital
- Study coordinator: Dou, Zhixun
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.