Understanding how chromatin dynamics affect skin cell development
Chromatin Dynamics During Epithelial Commitment
['FUNDING_R01'] · STANFORD UNIVERSITY · NIH-10975731
This study is looking at how skin cells made from special stem cells can be improved to help heal chronic wounds in people with a skin condition called Recessive Dystrophic Epidermolysis Bullosa, aiming to make better skin grafts for faster and more effective healing.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STANFORD UNIVERSITY (nih funded) |
| Locations | 1 site (STANFORD, UNITED STATES) |
| Trial ID | NIH-10975731 on ClinicalTrials.gov |
What this research studies
This research investigates the role of chromatin dynamics in the differentiation of skin cells derived from induced pluripotent stem cells (iPSCs) to develop effective treatments for chronic wounds in patients with Recessive Dystrophic Epidermolysis Bullosa. The project focuses on understanding the interactions between different cell lineages and transcription factors that influence skin cell development. By identifying key factors that enhance the production of graftable skin tissue, the research aims to improve the manufacturing process and reduce variability in skin grafts. Patients may benefit from advancements in skin grafting techniques that could lead to better healing outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients suffering from Recessive Dystrophic Epidermolysis Bullosa who experience non-healing wounds.
Not a fit: Patients with other types of skin conditions or those not experiencing chronic wounds may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved skin grafting techniques that enhance healing for patients with chronic wounds.
How similar studies have performed: Previous research has shown promise in using induced pluripotent stem cells for skin regeneration, indicating that this approach has potential for success.
Where this research is happening
STANFORD, UNITED STATES
- STANFORD UNIVERSITY — STANFORD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ORO, ANTHONY E — STANFORD UNIVERSITY
- Study coordinator: ORO, ANTHONY E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.