Understanding how chromatin dynamics affect skin cell development
Official title: Chromatin Dynamics During Epithelial Commitment
Funded at Stanford University · NIH-10975731 · Data updated 2026-11-12
This study is looking at how skin cells made from special stem cells can be improved to help heal chronic wounds in people with a skin condition called Recessive Dystrophic Epidermolysis Bullosa, aiming to make better skin grafts for faster and more effective healing.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | September 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $598,859 |
| NIH project number | 2R01AR073170-06A1 |
| Project ID | NIH-10975731 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients suffering from Recessive Dystrophic Epidermolysis Bullosa who experience non-healing wounds.
✕Less likely to help
Patients with other types of skin conditions or those not experiencing chronic wounds may not benefit from this research.
What this research studies
This research investigates the role of chromatin dynamics in the differentiation of skin cells derived from induced pluripotent stem cells (iPSCs) to develop effective treatments for chronic wounds in patients with Recessive Dystrophic Epidermolysis Bullosa. The project focuses on understanding the interactions between different cell lineages and transcription factors that influence skin cell development. By identifying key factors that enhance the production of graftable skin tissue, the research aims to improve the manufacturing process and reduce variability in skin grafts. Patients may benefit from advancements in skin grafting techniques that could lead to better healing outcomes.
Why it matters
Potential benefit: If successful, this research could lead to improved skin grafting techniques that enhance healing for patients with chronic wounds.
How similar studies have gone: Previous research has shown promise in using induced pluripotent stem cells for skin regeneration, indicating that this approach has potential for success.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Oro, Anthony E — Stanford University
- Study coordinator: Oro, Anthony E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.