Understanding how chromatin changes in Ewing sarcoma, a type of bone cancer in children and young adults.
Official title: Developmental control of chromatin states in cancer
Funded at Univ of North Carolina Chapel Hill · NIH-10994626 · Data updated 2026-11-12
This study is looking at how a gene fusion called EWS-FLI1 affects the way cancer cells behave in Ewing sarcoma, a type of bone cancer that mostly affects kids and young adults, to find new ways to help treat this disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $424,710 |
| NIH project number | 5R01CA276663-03 |
| Project ID | NIH-10994626 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children and young adults diagnosed with Ewing sarcoma.
✕Less likely to help
Patients with other types of cancer or those who do not have Ewing sarcoma may not benefit from this research.
What this research studies
This research investigates the role of chromatin states in Ewing sarcoma, a serious bone cancer affecting children and young adults. The study focuses on how a specific gene fusion, EWS-FLI1, influences the behavior of cancer cells by altering chromatin structure. By examining both cancer cells and stem cells, researchers aim to identify the proteins and RNA molecules that contribute to a chromatin environment that supports tumor growth. This approach could lead to new insights into the mechanisms of cancer development and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for Ewing sarcoma, potentially increasing survival rates and reducing the severity of the disease.
How similar studies have gone: Previous research has shown promising results in understanding chromatin dynamics in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Univ of North Carolina Chapel Hill
Chapel Hill, United States Active
Researchers
- Principal investigator: Davis, Ian J — Univ of North Carolina Chapel Hill
- Study coordinator: Davis, Ian J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.