Understanding how chromatin changes affect treatment responses in childhood tumors
Characterizing Chromatin Remodeling Mechanisms of Chemo-Sensitivity and Resistance in Pediatric Solid Tumors
This study is looking at how certain proteins in cancer cells might help make treatments work better for kids with tough tumors like rhabdoid tumors and alveolar rhabdomyosarcoma, and it’s testing a special medicine to see if it can improve how these tumors respond to chemotherapy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10884366 on NIH RePORTER |
What this research studies
This research investigates how chromatin remodeling complexes influence the effectiveness of cancer treatments in pediatric solid tumors, particularly focusing on rhabdoid tumors and alveolar rhabdomyosarcoma. The study aims to determine whether targeting these chromatin complexes can improve treatment outcomes by either enhancing sensitivity to chemotherapy or overcoming resistance. By using a compound called mithramycin, which inhibits a specific chromatin remodeling complex, the researchers hope to induce changes in the tumor's epigenetic landscape that could lead to better responses to existing therapies. This research could provide insights into new therapeutic strategies for children with these challenging cancers.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with rhabdoid tumors or alveolar rhabdomyosarcoma who are experiencing treatment resistance.
Not a fit: Patients with tumors that do not involve chromatin remodeling mechanisms or those who are not pediatric patients may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and outcomes for children with specific types of solid tumors.
How similar studies have performed: Other research has shown promising results in targeting chromatin remodeling complexes in various cancers, suggesting potential for success in this area as well.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Chasse, Maggie — Boston Children's Hospital
- Study coordinator: Chasse, Maggie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.