Understanding how chromatin affects stem cell function in the intestines
Chromatin regulation of epithelial stem cell function
['FUNDING_OTHER'] · EMORY UNIVERSITY · NIH-10877197
This study is looking at how certain changes in the DNA structure affect the behavior of stem cells in the intestines, which could help us understand how these cells keep renewing themselves and turning into different types of cells, ultimately helping with tissue healing and repair.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | EMORY UNIVERSITY (nih funded) |
| Locations | 1 site (ATLANTA, UNITED STATES) |
| Trial ID | NIH-10877197 on ClinicalTrials.gov |
What this research studies
This research investigates the role of chromatin modifications and associated enzymes in regulating stem cell behavior, particularly in the intestinal epithelium. By focusing on intestinal stem cells, the study aims to understand how these cells maintain their ability to self-renew and differentiate into various cell types. The researchers will utilize advanced genetic models to explore how specific transcription factors and chromatin landscapes influence cell identity and regenerative responses. This work could provide insights into the fundamental processes of tissue regeneration and repair.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include adults with conditions affecting the intestinal epithelium or those interested in the biology of stem cells.
Not a fit: Patients with non-epithelial related conditions or those outside the age range of 21+ years may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing tissue regeneration and treating diseases related to stem cell dysfunction.
How similar studies have performed: Other research has shown promising results in understanding stem cell regulation through chromatin modifications, indicating that this approach has potential for significant advancements.
Where this research is happening
ATLANTA, UNITED STATES
- EMORY UNIVERSITY — ATLANTA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GRACZ, ADAM DAVID — EMORY UNIVERSITY
- Study coordinator: GRACZ, ADAM DAVID
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers