Understanding how chromatin affects neuron development and growth.
Official title: Chromatin insulator-mediated epigenetic regulation of neuronal remodeling during development.
Funded at State University of New York at Buffalo · NIH-11021007 · Data updated 2026-11-12
This study is looking at how certain proteins help shape the way brain cells grow and develop, which could lead to better treatments for conditions that affect the brain.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of New York at Buffalo NIH-funded |
| Lab location | 1 site (Amherst, United States) |
| Project start | January 17, 2024 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $247,414 |
| NIH project number | 5R00HD097308-03 |
| Project ID | NIH-11021007 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals under 21 years old with neurodevelopmental disorders, such as autism spectrum disorder.
✕Less likely to help
Patients with fully developed neurological conditions or those over 21 years old may not benefit from this research.
What this research studies
This research investigates the role of chromatin insulators in the epigenetic regulation of neuronal remodeling during development. By using model systems like Drosophila and mice, the study aims to uncover how chromatin organization influences the maturation and outgrowth of neurons. The research focuses on specific proteins, such as CTCF and Shep, to understand their roles in promoting proper neuronal development. Insights gained from this research could lead to improved therapeutic strategies for neurodegenerative conditions.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance neuronal growth and repair, potentially improving quality of life for individuals with neurodegenerative diseases.
How similar studies have gone: Other research has shown promise in understanding chromatin's role in neuronal development, suggesting that this approach could yield valuable insights.
Where this research is happening
-
State University of New York at Buffalo
Amherst, United States Active
Researchers
- Principal investigator: Chen, Dahong — State University of New York at Buffalo
- Study coordinator: Chen, Dahong
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.