Understanding how chromatin affects gene regulation
Mechanisms of chromatin regulation of transcription
This study is looking at how the way our DNA is packaged can affect whether certain genes are turned on or off, which could help us understand diseases like cancer and aging better, so that patients can benefit from new treatments in the future.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-10917139 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which chromatin structure influences the accessibility of genes for transcription. By utilizing advanced experimental techniques, the team aims to understand how specific proteins interact with chromatin to regulate gene expression. The study focuses on the roles of pioneer transcription factors and epigenetic regulators in modifying chromatin to either promote or inhibit gene activity. Patients may benefit from insights gained into how these processes contribute to diseases like cancer and aging.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions influenced by gene regulation, including various cancers and age-related disorders.
Not a fit: Patients with conditions unrelated to chromatin regulation or gene expression may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases related to gene regulation, such as cancer.
How similar studies have performed: Previous research has shown promising results in understanding chromatin dynamics and their impact on gene regulation, indicating a strong foundation for this investigation.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Poirier, Michael Guy — Ohio State University
- Study coordinator: Poirier, Michael Guy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.