Understanding how chromatin affects gene activity and DNA repair in living cells
Chromatin Function During Transcription and DNA Repair at Single Molecule Resolutionin Living Cells
['FUNDING_U01'] · BOSTON CHILDREN'S HOSPITAL · NIH-10903826
This study is looking at how the structure of chromatin, which is the material that makes up our genes, affects how our cells read genes and fix DNA, helping us understand important processes for keeping our cells healthy.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BOSTON CHILDREN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10903826 on ClinicalTrials.gov |
What this research studies
This research investigates the role of chromatin, the material that makes up chromosomes, in regulating gene transcription and DNA repair processes within living cells. By using advanced imaging techniques, researchers will observe how chromatin organization and dynamics influence the binding of key proteins involved in these essential cellular functions. The study focuses on specific transcription factors and their interactions with chromatin, aiming to create predictive models based on real-time data collected during the experiments. This approach will help clarify the mechanisms behind gene expression and DNA repair, which are crucial for maintaining cellular health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic conditions or cancers that involve disruptions in gene transcription or DNA repair processes.
Not a fit: Patients with conditions unrelated to chromatin function or those not experiencing issues with gene transcription or DNA repair may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into genetic regulation and DNA repair mechanisms, potentially informing treatments for genetic disorders and cancer.
How similar studies have performed: Previous research has shown promising results in understanding chromatin dynamics and its impact on gene regulation, suggesting that this approach could yield valuable insights.
Where this research is happening
BOSTON, UNITED STATES
- BOSTON CHILDREN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HA, TAEKJIP — BOSTON CHILDREN'S HOSPITAL
- Study coordinator: HA, TAEKJIP
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.