Understanding how cholinergic systems relate to psychosis and cognitive issues in schizophrenia
Elucidating Cholinergic Relationships with Psychosis And Cognitive Deficits in Schizophrenia
['FUNDING_R01'] · STATE UNIVERSITY NEW YORK STONY BROOK · NIH-11127738
This study is looking at how certain brain systems related to a chemical called acetylcholine might affect symptoms of schizophrenia, like hallucinations and thinking problems, and it hopes to find new ways to diagnose and treat the condition with better medications.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STATE UNIVERSITY NEW YORK STONY BROOK (nih funded) |
| Locations | 1 site (STONY BROOK, UNITED STATES) |
| Trial ID | NIH-11127738 on ClinicalTrials.gov |
What this research studies
This research investigates the role of cholinergic systems in schizophrenia, focusing on how these systems may contribute to psychosis and cognitive deficits. By examining the vesicular acetylcholinergic transporter (VAChT) and using advanced imaging techniques like PET scans, the study aims to identify new biomarkers that could improve diagnosis and treatment. The research also explores the potential of new medications that target cholinergic activity to alleviate symptoms of schizophrenia, which may offer a novel approach beyond current treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with schizophrenia who experience cognitive deficits and psychotic symptoms.
Not a fit: Patients with schizophrenia who do not exhibit cognitive deficits or those who are not responsive to cholinergic treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for patients with schizophrenia, potentially reducing symptoms and enhancing cognitive function.
How similar studies have performed: Other research has shown promise in targeting cholinergic systems for treating schizophrenia, indicating that this approach may be viable.
Where this research is happening
STONY BROOK, UNITED STATES
- STATE UNIVERSITY NEW YORK STONY BROOK — STONY BROOK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WEINSTEIN, JODI JAY — STATE UNIVERSITY NEW YORK STONY BROOK
- Study coordinator: WEINSTEIN, JODI JAY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.