Understanding how cholinergic systems relate to psychosis and cognitive issues in schizophrenia
Official title: Elucidating Cholinergic Relationships with Psychosis And Cognitive Deficits in Schizophrenia
Funded at State University New York Stony Brook · NIH-11127738 · Data updated 2026-11-12
This study is looking at how certain brain systems related to a chemical called acetylcholine might affect symptoms of schizophrenia, like hallucinations and thinking problems, and it hopes to find new ways to diagnose and treat the condition with better medications.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project start | July 1, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $677,628 |
| NIH project number | 5R01MH137423-02 |
| Project ID | NIH-11127738 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with schizophrenia who experience cognitive deficits and psychotic symptoms.
✕Less likely to help
Patients with schizophrenia who do not exhibit cognitive deficits or those who are not responsive to cholinergic treatments may not benefit from this research.
What this research studies
This research investigates the role of cholinergic systems in schizophrenia, focusing on how these systems may contribute to psychosis and cognitive deficits. By examining the vesicular acetylcholinergic transporter (VAChT) and using advanced imaging techniques like PET scans, the study aims to identify new biomarkers that could improve diagnosis and treatment. The research also explores the potential of new medications that target cholinergic activity to alleviate symptoms of schizophrenia, which may offer a novel approach beyond current treatments.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for patients with schizophrenia, potentially reducing symptoms and enhancing cognitive function.
How similar studies have gone: Other research has shown promise in targeting cholinergic systems for treating schizophrenia, indicating that this approach may be viable.
Where this research is happening
-
State University New York Stony Brook
Stony Brook, United States Active
Researchers
- Principal investigator: Weinstein, Jodi Jay — State University New York Stony Brook
- Study coordinator: Weinstein, Jodi Jay
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.